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Evidence supporting the efficacy and safety of this combination product in the treatment of multiple recurrent headaches is unavailable. It is a shorttointermediate acting member of barbiturates that exhibit musclerelaxing and antianxiety properties that produce central nervous system cns depression that ranges from mild sedation to general anesthesia. Butalbital, acetaminophen, and caffeine tablets, usp contain 50 mg butalbital, 325 mg acetaminophen, and 40 mg caffeine. Acetaminophen, butalbital, and caffeine is a combination medicine used to treat tension headaches that are caused by muscle contractions. Butalbital acetaminophen caffeine medicare coverage. It is one of the most common active drug ingredients in the u.
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